Yes. It is necessary to submit an explanation including whether the new chemical substance has comparable or obvious advantages in terms of performance and environmental friendliness compared with the chemical substance in use for the same purpose, so as to fully demonstrate the necessity of the application activity.

No. It is recommended that more data be used for a more accurate assessment of the substance.

The aquatic toxicity, carcinogenicity, mutagenicity, reproductive toxicity, chronic toxicity and specific target organ toxicity of the substance will affect the determination of the toxicity of the substance. Please consult us for specific determination criteria.

The log kow value of a substance can be used to screen the bioaccumulation of a substance, and the BCF value is the criterion for the bioaccumulation of a substance. Please consult Boardingcard for the specific determination process.

Persistence determination is a complex and highly professional work. According to determination standards and screening criteria, the screening evaluation process is used for determination. The basic data requirements in the "Guideline" can only be used to determine the screening criteria, and cannot be directly determined based on the criteria. When evaluating a substance, we need to use the weight of evidence method to determine based on the structure, properties, existing data, QSAR, and cross-reference of the substance. For details, please consult Boardingcard.